Liverpool moved level on points with Premier League leaders Tottenham Hotspur and thwarted Leicester City's hopes of going top with an outstanding performance and victory at Anfield.
Jurgen Klopp's side remain behind Spurs on goal difference but the manner of the win sounded an ominous warning to those hoping to wrest the title away from the champions.
Liverpool also established a new club record of 64 home league games unbeaten, breaking their previous best run, which was set between February 1978 and January 1981 and itself ended by Leicester.
And they achieved this latest win amid a squad crisis that has robbed them of Virgil van Dijk, Trent Alexander-Arnold, Joe Gomez, Jordan Henderson, Thiago Alcantara and Mohamed Salah.
"There were a lot of good things. I can't pick one that pleased me most - maybe the performance of James Milner at right-back," Klopp said.
"He played an exceptional game, first there and then in midfield. That is what we expect from ourselves.
"The injuries were a massive shock in that moment but the boys have to offer solutions. We have centre-halves, they are really young. They are not experienced, you saw the bench tonight."
Klopp's side took the lead midway through the first half when Jonny Evans nodded a corner into his own net and the advantage was doubled four minutes before half-time when a move of 30 passes ended with Diogo Jota heading in Andrew Robertson's superb cross.
Liverpool added Salah to their long list of absentees after he tested positive for Covid-19 in Egypt but the prolific Jota, signed from Wolves for £45m in September, once again stepped in - becoming the first player in the club's history to score in his first four competitive home appearances.
Leicester improved marginally in the second half but it was still Liverpool who dominated, Evans heading against his own post and both Roberto Firmino and Sadio Mane being denied by the woodwork and keeper Kasper Schmeichel.
Firmino was finally on target as he rose to send a fine header out of Schmeichel's reach four minutes from time to give Liverpool the victory margin their superiority deserved.
BDST: 1218 HRS, NOV 23, 2020